Inflammation : The Root Cause of most Joint, Hip & Over-Training Problems
Conditions such as Joint and Hip Pain, Arthritis, Allergies, Asthma, Heart Disease, Gingivitis, Autoimmune Disorder, and Lupus are seemingly diverse, but they share a central link: inflammation. Each year, researchers uncover more diseases where inflammation is a pivotal factor.
Inflammation is the body's initial response to infection or injury. When one sustains a cut, for example, bacteria may enter the wounded tissue, prompting an immediate immune response. The immune system activates a series of specialized cells, including:
- Mast cells that release histamine and cytokines, signalling the body about the injury. Histamine primarily boosts blood flow, leading to the observed redness and swelling.
- Macrophages (often called 'large eating cells') migrate to the site, secreting messengers that neutralize the bacteria and clear up the injured zone.
- Other immune cells then join the fray, battling the invaders, and commencing the healing process.
This protective process manifests as redness, heat, swelling, and often pain at the site of injury:
- Redness results from increased blood flow.
- Heat signifies the ongoing fight against bacteria.
- Swelling indicates fluid and cell build-up.
- Pain serves as an inflammation marker.
Inflammation is commonly seen in cases of sunburns, twisted ankles, insect bites, or
due to over-training.
While inflammation is an essential protective response, chronic or unresolved inflammation can harm healthy tissues. Prolonged inflammation can give rise to other diseases, targeting joints, organs, or arteries.
Root Causes of Inflammation: Beyond physical injuries, various external and internal factors can trigger inflammation. These include stress, parasites, bacteria, environmental toxins, excessive sugar intake, obesity, smoking, and heightened blood insulin levels.
Diet also plays a crucial role. Foods rich in arachidonic acid, such as eggs, beef, dairy, and organ meats, can spur inflammation. The body metabolizes arachidonic acid into inflammatory agents like prostaglandin and leukotrienes.
Over-cooked or high-temperature fried foods can provoke inflammation due to the formation of AGES (Advanced Glycation End Products). The body occasionally identifies AGES as threats, triggering an immune response. Persistent exposure can lead to diseases often misattributed to aging, like arthritis, cataracts, memory loss, heart disease, or even skin aging.
The Pain Management Industry: The primary aim of pharmaceutical companies has been producing pain-relief drugs. The over-the-counter pain relief industry in North America alone amounted to over 3.9 billion dollars in 2005, with Acetaminophen leading the sales, followed by Ibuprofen and Aspirin. Notably, arthritis patients are the largest consumers of pain medications.
However, these NSAIDs (non-steroidal anti-inflammatory drugs) are not without risks. Prolonged or excessive usage can lead to liver damage, kidney failure, and other serious side effects, resulting in over 20,000 annual deaths in the USA.
Introducing Kre-Celazine® a patented, clinically tested ingredient that offers a natural
solution for pain reduction and enhanced joint health. It blends Kre-Alkalyn® with esterified fatty acid carbons, ensuring stability against oxidation. Kre-Celazine® is pivotal in combating inflammation, which, when chronic, can expedite degenerative diseases and potentially shorten life spans.
Opt for PrimeFlex RA ™for:
- Direct resolution of joint issues
- Enhanced mobility and flexibility
- Powerful ingredients ensuring optimum results
- Simple daily consumption to fit your routine
- Comprehensive support for the active lifestyle
- Easy consumption, suck swallow or chew tailored to user preference
Note: the buffered creatine base found in kre-celazine® may give extra energy as a welcome side-effect. PRIME+EASE™ is available as a milder alternative if required.
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Prime Flex has been transformative. The unique blend has notably eased my joint pain
- Cliff T, Swindon, UK
This supplement is integral to my routine. I’ve experienced less discomfort after long runs.
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Studies
Turmeric Extract (Curcumin)
- Training & Recovery: Curcumin's antioxidant properties help reduce exercise-induced oxidative stress ("Effects of curcumin supplementation on exercise-induced oxidative stress in humans", International Journal of Sports Medicine, 2014).
- Joint/Hip Support: It's known to alleviate osteoarthritis pain ("Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis," Journal of Alternative and Complementary Medicine, 2009).
- Arthritis & RA: Curcumin demonstrates benefits for RA ("Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis", Journal of Natural Products, 2006).
Hyaluronic Acid:
- Joint/Hip Support: Demonstrated efficacy in reducing osteoarthritic knee pain ("Intra-articular hyaluronic acid in treatment of knee osteoarthritis", Journal of the American Medical Association, 2003).
Rose Hips Extract:
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Joint/Hip Support: The extract reduces osteoarthritis pain ("Rose hip alleviates pain in osteoarthritis patients", Osteoarthritis and Cartilage, 2008).
- Arthritis & RA: It has shown potential in reducing stiffness in RA ("Standardized rose hip powder reduces pain and stiffness in osteoarthritis", Scandinavian Journal of Rheumatology, 2005).
Boswellia:
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Joint/Hip Support: It's beneficial for osteoarthritis patients ("Boswellia serrata extract for treating knee osteoarthritis", Phytomedicine, 2014).
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Arthritis & RA: Boswellia has shown promise for RA treatment ("Boswellia serrata in treatment of rheumatoid arthritis", Phytomedicine, 1996).
Green Lipped Mussel Extract:
- Joint/Hip Support: It alleviates symptoms in knee osteoarthritis ("Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis", Inflammopharmacology, 2012).
MSM (Methylsulfonylmethane):
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Joint/Hip Support: MSM provides relief from osteoarthritis pain ("Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee", Journal of the International Society of Sports Nutrition, 2011).
Resveratrol:
- Training & Recovery: Resveratrol has been found to enhance exercise training ("Resveratrol supplementation improves white adipose tissue function" American Journal of Physiology-Regulatory, 2018).
- Arthritis & RA: It offers protective effects against arthritic damage ("Therapeutic potential of resveratrol in rheumatoid arthritis", Clinical Immunology, 2019).
Devil's Claw Extract:
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Joint/Hip Support: Harpagophytum procumbens (Devil's Claw) has shown efficacy in chronic pain conditions ("A systematic review on the efficacy of Harpagophytum procumbens (Devil's Claw) on chronic pain". Phytomedicine, 2006).